Author

J. J. Zhao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Ni· 2 shared J. S. Bergholz· 2 shared L. C. Cantley· 2 shared Q. Wang· 2 shared T. Jiang· 2 shared A. Ali· 1 shared A. Friedman· 1 shared A. L. K. Tan· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

J. Ni

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Author profile →

5 papers

Recent·Most cited

Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases

J. J. Zhao, J. C.-A. Ong, S. Srivastava, D. K. A. Chia, H. Ma, K. K. Huang, T. Sheng, K. Ramnarayanan, X. Ong, S. T. Tay, T. Hagihara, A. L. K. Tan, M. C. C. Teo, Q. X. Tan, G. W. X. Ng, , R. Sundar

This study identifies transcriptomic and immune features of gastric cancer peritoneal metastases, highlighting predictive markers and therapeutic targets in the tumor microenvironment.

bioRxiv · Mar 21, 2024Cancer Biology

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

X. He, Y. Wei, J. Wu, Q. Wang, J. S. Bergholz, H. Gu, J. Zou, S. Lin, W. Wang, S. Xie, T. Jiang, J. Lee, J. M. Asara, K. Zhang, L. C. Cantley, J. J. Zhao

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

bioRxiv · Jun 27, 2023Biochemistry

Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI

J. Ni, Y. Wang, Q. Wang, J. S. Bergholz, T. Jiang, T. M. Roberts, N. S. Gray, J. J. Zhao

This paper introduces a novel EGFR-TKI, CM93, which shows improved brain penetration and efficacy against EGFR-mutated glioblastoma in vitro and in vivo.

bioRxiv · Jan 9, 2021 · PreprintCancer Biology

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

W. Kang, Y. Fan, Y. Du, E. A. Tonkova, Y.-H. Hsu, K. V. Tan, S. Alexander, B. S. Wong, H. Yang, J. Luo, K. Yao, J. Yang, X. Hu, T. Liu, Y. Gan, , Z. Gu

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

bioRxiv · Aug 27, 2020 · PreprintCancer Biology

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

bioRxiv · Mar 3, 2020 · PreprintCancer Biology