Author

S. Dentro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:clustering· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

M. Gerstung· 4 shared A. Herms· 3 shared D. Fernandez-Antoran· 3 shared S. H. Ong· 3 shared B. A. Hall· 2 shared B. Colom· 2 shared C. King· 2 shared K. Murai· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

M. Gerstung

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Author profile →

5 papers

Recent·Most cited

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

A. Herms, D. Fernandez-Antoran, M. Alcolea, A. Kalogeropoulou, U. Banerjee, G. Piedrafita, E. Abby, J. A. Valverde-Lopez, I. S. Ferreira, S. Dentro, S. H. Ong, B. Colom, K. Murai, C. King, K. T. Mahbubani, , P. H. Jones

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

bioRxiv · Jan 3, 2023Cell Biology

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

K. Murai, S. Dentro, S. H. Ong, R. Sood, D. Fernandez-Antoran, A. Herms, V. Kostiou, B. A. Hall, M. Gerstung, P. H. Jones

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

bioRxiv · Feb 3, 2022Cancer Biology

Clonal diversification and histogenesis of malignant germ cell tumours

T. R. W. Oliver, L. Chappell, R. Sanghvi, L. Deighton, N. Ansari-Pour, S. Dentro, M. D. Young, T. H. H. Coorens, H. Jung, T. M. Butler, M. D. C. Neville, D. Leongamornlert, M. A. Sanders, Y. Hooks, A. Cagan, , S. Behjati

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

bioRxiv · Feb 1, 2022Cancer Biology

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

B. Colom, A. Herms, S. Dentro, C. King, R. Sood, M. Alcolea, D. Fernandez-Antoran, S. H. Ong, J. C. Fowler, K. Mahbubani, K. Saeb-Parsy, M. Gerstung, B. A. Hall, P. Jones

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

bioRxiv · Jun 25, 2021Cancer Biology

Spatial genomics maps the structure, character and evolution of cancer clones

A. Lomakin, J. Svedlund, C. Strell, M. Gataric, A. Shmatko, J. S. Park, Y. S. Ju, S. Dentro, V. Kleshchevnikov, V. Vaskivskyi, T. Li, O. A. Bayraktar, L. Moore, S. Pinder, A. L. Richardson, , L. R. Yates

The paper develops a spatial genomics method to map cancer clone structure, character, and evolution across breast cancer progression stages.

bioRxiv · Apr 16, 2021 · PreprintCancer Biology