Author

J. Saint-Paul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Granier· 3 shared B. Mouillac· 2 shared C. LEYRAT· 2 shared H. Orcel· 2 shared J. Bous· 2 shared P. Bron· 2 shared R. SOUNIER· 2 shared S. Fontanel· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

S. Granier

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3 papers

Recent·Most cited

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

J. Bous, A. Fouillen, H. Orcel, S. Trapani, X. Cong, S. Fontanel, J. Saint-Paul, J. LAI KEE HIM, S. Urbach, N. Sibille, R. SOUNIER, S. Granier, B. Mouillac, P. Bron

The paper reports the cryo-EM structure of the V2 receptor-{beta}-arrestin1 complex, revealing structural variability in GPCR-arrestin interactions.

bioRxiv · Feb 11, 2022Biochemistry

Discovery and mechanism of action of small molecule inhibitors of ceramidases

S. Granier, R. D. Healey, E. Saied, X. Cong, G. Karsai, L. Gabellier, J. Saint-Paul, E. Del Nero, S. Jeannot, M. Drapeau, S. Fontanel, D. Maurel, S. Basu, C. LEYRAT, G. Bossis, , C. Arenz

The paper discovers small molecule inhibitors of alkaline ceramidase 3 using fluorescent substrates and characterizes their mechanism of action.

bioRxiv · Jun 15, 2021Biochemistry

Structure of the antidiuretic hormone vasopressin receptor signalling complex.

J. Bous, H. Orcel, N. Floquet, C. Leyrat, J. Lai-Kee-Him, G. Gaibelet, A. Ancelin, J. Saint-Paul, S. Trapani, M. Louet, R. Sounier, H. Demene, S. Granier, P. Bron, B. Mouillac

The paper reports the structure of the AVP-V2R-Gs complex using cryo-EM, revealing distinct conformations and a unique receptor-Gs interface that explains genetic disease variants.

bioRxiv · Dec 22, 2020 · PreprintBiochemistry