Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate
P. Kumar, M. Wang, O. S. Kumru, J. Hickey, J. Sanmiguel, N. Zabaleta, L. H. Vandenberghe, S. B. Joshi, D. B. Volkin
The paper correlates physicochemical properties of an rAAV vaccine candidate with its biological potency, showing links between physical stability, transduction efficiency, and immunogenicity.
bioRxiv · Mar 10, 2023Immunology