W. Qi

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

Heterogeneous and Novel Transcript Expression in Single Cells of Patient-Derived ccRCC Organoids

This study uses single-cell long-read sequencing to analyze transcriptomes of ccRCC organoids, identifying novel transcripts and highlighting cell-specific alternative splicing events.

Candida albicans' inorganic phosphate transport and evolutionary adaptation to phosphate scarcity

This study identifies phosphate transporters in Candida albicans and shows how mutations in these genes affect growth and stress resistance under phosphate scarcity.

Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model

This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.

Reactive oxygen species accelerate de novo acquisition of antibiotic resistance in E. coli

This study shows that reactive oxygen species from sublethal antibiotics promote de novo resistance in E. coli by increasing DNA damage and mutation rates.

The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

This study identifies BTRC as an E3 ligase that promotes ATGL proteasomal degradation, contributing to hepatic steatosis in NAFLD, and suggests BTRC as a potential therapeutic target.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

Guild-level microbiome signature associated with COVID-19 severity and prognosis

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

Haplotype resolved DNA methylome of African cassava genome

This study presents a haplotype-resolved DNA methylome of the African cassava genome using long-read sequencing and chromosomal conformation capture techniques.

Genomic local adaptation of a generalist plant species to pollinator communities and abiotic factors

This study identifies genetic variants in Brassica incana associated with pollinator interactions and abiotic factors using genome-environmental association analysis and selection scans.

Heterogeneity of RNA editing in mesothelioma and how RNA editing enzyme ADAR2 affects mesothelioma cell growth, response to chemotherapy and tumor microenvironment

This study examines RNA editing heterogeneity in mesothelioma and shows ADAR2's role in cell growth, chemotherapy response, and tumor microenvironment regulation.

Mutations in DNA polymerase δ subunit 1 mediate CMD2-type resistance to Cassava Mosaic Geminiviruses

The paper identifies a nonsynonymous SNP in MePOLD1 as the causal mutation for CMD2-type resistance to Cassava Mosaic Geminiviruses, validated through virus-induced gene silencing and allele analysis.

Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats

This study shows that the N-terminal HEAT repeats of Tor1 kinase in C. albicans are essential for stress and metabolic responses, with loss of these repeats impairing certain stress responses and metabolic adaptations.

The connection between Rap1 and Talin1 in CD4+ T Lymphocytes

This study investigates the role of Rap1-talin1 interactions and RIAM in integrin activation in CD4+ T cells, showing that RIAM can substitute for Rap1 binding in some contexts.

Bioengineering of genetically encoded gene promoter repressed by flavonoids for constructing intracellular sensor for molecular events

The paper develops a synthetic gene promoter repressed by flavonoids to create an intracellular sensor for molecular events.

Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates

This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.

Reactive oxygen species as important regulators of cell division

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

Two Receptor-Like Kinases Required For Arabidopsis Endodermal Root Organisation Shape The Rhizosphere Microbiome

This study identifies ERK1 and RBK1 as key regulators of Casparian Strip formation in Arabidopsis, which in turn influences rhizosphere microbiome composition.

Graphene Quantum Dot Oxidation Governs Noncovalent Biopolymer Adsorption

This study investigates how oxidation levels of graphene quantum dots (GQDs) affect noncovalent adsorption of single-stranded DNA, showing strong adsorption on unoxidized GQDs and none on heavily oxidized ones.

Vector-Mediated Transport Producing Drug-like Peptides

This paper develops a vector-mediated transport approach to create drug-like peptides with oral activity, blood-brain-barrier transport, and extended in vivo half-life.

IL-25 induces beige fat to improve metabolic homeostasis via macrophage and innervation

This study shows IL-25 promotes beige fat browning through macrophage activation and innervation, improving metabolic homeostasis in obese mice.

Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence

This study shows that Pho84 in Candida albicans affects virulence by modulating oxidative stress through Sod3 and TORC1 pathways.

A platform for efficient transgenesis in Macrostomum lignano, a flatworm model organism for stem cell research

This paper develops a transgenesis method for Macrostomum lignano and annotates its genome to enable genetic studies on stem cells and regeneration.