Author

J. Spinelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Chakraborty· 1 shared A. Creech· 1 shared A. Ringel· 1 shared B. Olenchock· 1 shared D. Kim· 1 shared J. A. Olzmann· 1 shared J. Jaffe· 1 shared M. B. Doshi· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Chakraborty

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2 papers

Recent·Most cited

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

N. Lee, S. J. Park, M. Lange, T. Tseyang, M. B. Doshi, T. Kim, Y. Song, D. Kim, P. L. Greer, J. A. Olzmann, J. Spinelli, D. Kim

The paper shows selenium reduces ubiquinone to ubiquinol via SQOR, protecting against ferroptosis independently of selenoprotein production.

bioRxiv · Apr 13, 2023Biochemistry

The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate

A. Chakraborty, T. Laukka, M. Myllykoski, A. Ringel, M. Booker, M. Tolstorukov, Y. Meng, S. Meier, R. Jennings, A. Creech, Z. Herbert, J. Spinelli, S. McBrayer, B. Olenchock, J. Jaffe, , W. G. Kaelin

The paper shows that KDM6A, an H3K27 histone demethylase, is oxygen-sensitive and its inactivation under hypoxia affects chromatin and cell fate.

bioRxiv · Jan 3, 2019 · PreprintBiochemistry