Author

L. Naesens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Stevaert· 2 shared A. Voet· 1 shared B. Krasniqi· 1 shared B. Van Loy· 1 shared B. Vanmechelen· 1 shared D. Jochmans· 1 shared J. Schepers· 1 shared J. Stroobants· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

A. Stevaert

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Author profile →

3 papers

Recent·Most cited

Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening

B. Vanmechelen, J. Stroobants, W. Chiu, L. Naesens, J. Schepers, K. Vermeire, P. Maes

This paper develops a biologically contained Marburg virus system for high-throughput antiviral screening and validates its safety and utility.

bioRxiv · Jul 29, 2022Microbiology

Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonuclease

B. Krasniqi, A. Stevaert, B. Van Loy, T. Nguyen, J. Thomas, J. Vandeput, D. Jochmans, V. Thiel, R. Dijkman, W. Dehaen, A. Voet, L. Naesens

This study identifies betulonic acid derivatives as inhibitors of coronavirus replication by targeting the nsp15 endoribonuclease, with EC50 of 0.6 M against 229E.

bioRxiv · Dec 10, 2020Microbiology

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

M. Laporte, A. Stevaert, V. Raeymaekers, R. Van Berwaer, K. Martens, S. Pöhlmann, L. Naesens

This paper identifies how SARS-CoV-2 and other coronaviruses' spike proteins are adapted to specific airway temperatures and proteases, enhancing their transmission and pathogenicity.

bioRxiv · Nov 9, 2020Microbiology