Author

J. Tenthorey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:mouse· 1

Frequent Co-Authors

H. S. Malik· 2 shared M. Emerman· 2 shared A. Sodeinde· 1 shared C. Liu· 1 shared C. Young· 1 shared H. Klingenberg· 1 shared I. Ramzan· 1 shared I. Rauch· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersEvolutionary Biology

H. S. Malik

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3 papers

Recent·Most cited

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

J. Tenthorey, S. del Banco, I. Ramzan, H. Klingenberg, C. Liu, M. Emerman, H. S. Malik

The paper shows that indels, not just missense mutations, enable antiviral proteins like TRIM5 to evolve new functions against viruses.

bioRxiv · May 7, 2024Evolutionary Biology

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

J. Tenthorey, C. Young, A. Sodeinde, M. Emerman, H. S. Malik

The paper uses deep mutational scanning to assess how mutations in the TRIM5 v1 loop affect retroviral restriction, finding that most mutations enhance or preserve antiviral function.

bioRxiv · Jun 12, 2020Evolutionary Biology

New mutant mouse models clarify the role of NAIPs, phosphorylation, NLRP3, and tumors in NLRC4 inflammasome activation

J. Tenthorey, R. A. Chavez, T. W. Thompson, K. A. Deets, R. E. Vance, I. Rauch

This study uses genetic models to show that NLRC4 phosphorylation and NLRP3 do not play a role in NAIP/NLRC4 inflammasome activation or anti-tumor responses.

bioRxiv · Sep 18, 2019Immunology