New mutant mouse models clarify the role of NAIPs, phosphorylation, NLRP3, and tumors in NLRC4 inflammasome activation
J. Tenthorey, R. A. Chavez, T. W. Thompson, K. A. Deets, R. E. Vance, I. Rauch
This study uses genetic models to show that NLRC4 phosphorylation and NLRP3 do not play a role in NAIP/NLRC4 inflammasome activation or anti-tumor responses.
bioRxiv · Sep 18, 2019Immunology