Author

J. Thekkiniath

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Ben Mamoun· 2 shared P. Singh· 2 shared P. Vydyam· 2 shared S. Gihaz· 2 shared A. Chattopadhyay Pal· 1 shared A. Nilsen· 1 shared A. Sanchez-Flores· 1 shared B. A. Tejo· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

C. Ben Mamoun

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tetra hydroxy ethyl disulfate disodium: a novel non-resistant antibacterial chelating agent

Kholis Abdurachim Audah, G. E. Jogia, D. Kustaryono, J Amsyir, SA Amalda, Jason Darmadi, Sandiego Himawan, Syafiqah Saidin, B. A. Tejo, Cahyo Budiman, Sarah Singh, J. Thekkiniath

This study identifies THES as a non-resistant antibacterial agent that disrupts bacterial cell membranes through chelation, showing efficacy against MDR bacteria without resistance development.

bioRxiv · Jun 4, 2024 · PreprintBiochemistry

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

S. Lonardi, P. Singh, Q. Liang, P. Vydyam, E. Khabirova, T. Fang, S. Gihaz, J. Thekkiniath, M. Munshi, S. Abel, G. Batugedara, M. Gupta, X. M. Lu, T. Lenz, S. Chakravarty, , C. Ben Mamoun

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

bioRxiv · May 9, 2022Microbiology

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

J. E. Chiu, I. Renard, A. Chattopadhyay Pal, P. Singh, P. Vydyam, J. Thekkiniath, M. Kumar, S. Gihaz, S. Pou, R. W. Winter, R. Dodean, A. Nilsen, M. K. Riscoe, J. S. Doggett, C. Ben Mamoun

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

bioRxiv · Mar 31, 2021Microbiology