Author

C. Ben Mamoun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

P. Singh· 6 shared P. Vydyam· 6 shared S. Gihaz· 4 shared E. Cornillot· 3 shared I. Renard· 3 shared K. G. Le Roch· 3 shared S. Abel· 3 shared A. Chattopadhyay Pal· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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6 shared papersMicrobiology

P. Singh

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Multiomics analysis reveals B. MO1 as a distinct Babesia species and provides insights into its evolution and virulence.

P. Singh, P. Vydyam, T. Fang, M. Kumar, K. Estrada, R. Grande, A. Sanchez-Flores, L. M. Gonzalez, E. Montero, S. Chakravarty, S. Lonardi, V. Berry, V. Ranwez, B. Carcy, D. Depoix, , C. Ben Mamoun

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

Emerging Microbes & Infections · Sep 1, 2024Peer-reviewedMicrobiology

DAB-APT: a Fluorescence-Based Assay for Determining Aminopropyl Transferase Activity and Inhibition

P. Singh, J.-Y. Choi, C. Ben Mamoun

The paper develops a fluorescence-based assay, DAB-APT, to measure aminopropyl transferase activity and inhibition, validated with enzymes from S. cerevisiae and P. falciparum.

bioRxiv · Apr 9, 2024Biochemistry

In Vitro Efficacy of Next Generation Dihydrotriazines and Biguanides Against Babesiosis and Malaria Parasites

P. Vydyam, M. Chand, S. Gihaz, I. Renard, G. D. Heffernan, L. R. Jacobus, D. P. Jacobus, K. W. Saionz, R. Shah, H.-M. Shieh, J. Terpinski, W. Zhao, E. Cornillot, C. Ben Mamoun

This study screens dihydrotriazines and biguanides against Babesia and Plasmodium parasites to identify effective antifolates with broad-spectrum activity and high therapeutic indices.

bioRxiv · Mar 20, 2024Microbiology

Activation of Macrophages by Extracellular Vesicles Derived from Babesia-infected Red Blood Cells

B. Hagos, I. Brasov, H. Branscome, F. Kashanchi, C. Ben Mamoun, R. E. Molestina

This study investigates whether extracellular vesicles from Babesia-infected red blood cells activate macrophages and modulate cytokine secretion.

bioRxiv · Feb 19, 2024Microbiology

Vitamin B5 Metabolism is Essential for Vacuolar and Mitochondrial Integrity and Xenobiotic Detoxification in Fungi

J.-Y. Choi, S. Gihaz, M. Munshi, P. Singh, P. Vydyam, P. Hamel, E. M. Adams, K. Fuller, C. Ben Mamoun

This study shows that disrupting the PCA pathway in fungi affects vacuolar integrity, drug detoxification, and susceptibility to antifungal drugs, supporting its potential as a therapeutic target.

bioRxiv · Dec 10, 2023 · PreprintMicrobiology

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin, J. H. Chung, G. L. Barnes, M. E. Daub, I. Renard, J. Y. Choi, P. Vydyam, A. Chattopadhyay Pal, M. Argomaniz, C. Banks, J. kirkwood, A. Saraf, I. Camino Diaz, , K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

Spermidine Is The Main Polyamine Required By Intracellular Parasites For Survival Within Host Erythrocytes

P. Singh, C. Ben Mamoun

This study identifies spermidine as essential for survival of intracellular parasites in human erythrocytes, showing it regulates protein translation via hypusination of eIF5A.

bioRxiv · Feb 1, 2023 · PreprintMicrobiology

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

S. Lonardi, P. Singh, Q. Liang, P. Vydyam, E. Khabirova, T. Fang, S. Gihaz, J. Thekkiniath, M. Munshi, S. Abel, G. Batugedara, M. Gupta, X. M. Lu, T. Lenz, S. Chakravarty, , C. Ben Mamoun

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

bioRxiv · May 9, 2022Microbiology

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

J. E. Chiu, I. Renard, A. Chattopadhyay Pal, P. Singh, P. Vydyam, J. Thekkiniath, M. Kumar, S. Gihaz, S. Pou, R. W. Winter, R. Dodean, A. Nilsen, M. K. Riscoe, J. S. Doggett, C. Ben Mamoun

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

bioRxiv · Mar 31, 2021Microbiology