Author

S. Gihaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Ben Mamoun· 4 shared P. Vydyam· 4 shared P. Singh· 3 shared E. Cornillot· 2 shared I. Renard· 2 shared J. Thekkiniath· 2 shared M. Munshi· 2 shared A. Ayali· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

C. Ben Mamoun

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

In Vitro Efficacy of Next Generation Dihydrotriazines and Biguanides Against Babesiosis and Malaria Parasites

P. Vydyam, M. Chand, S. Gihaz, I. Renard, G. D. Heffernan, L. R. Jacobus, D. P. Jacobus, K. W. Saionz, R. Shah, H.-M. Shieh, J. Terpinski, W. Zhao, E. Cornillot, C. Ben Mamoun

This study screens dihydrotriazines and biguanides against Babesia and Plasmodium parasites to identify effective antifolates with broad-spectrum activity and high therapeutic indices.

bioRxiv · Mar 20, 2024Microbiology

Vitamin B5 Metabolism is Essential for Vacuolar and Mitochondrial Integrity and Xenobiotic Detoxification in Fungi

J.-Y. Choi, S. Gihaz, M. Munshi, P. Singh, P. Vydyam, P. Hamel, E. M. Adams, K. Fuller, C. Ben Mamoun

This study shows that disrupting the PCA pathway in fungi affects vacuolar integrity, drug detoxification, and susceptibility to antifungal drugs, supporting its potential as a therapeutic target.

bioRxiv · Dec 10, 2023 · PreprintMicrobiology

Decoding The Nuclear Genome of The Human Pathogen Babesia duncani Shed Light on its Virulence, Drug Susceptibility and Evolution among Apicomplexa

S. Lonardi, P. Singh, Q. Liang, P. Vydyam, E. Khabirova, T. Fang, S. Gihaz, J. Thekkiniath, M. Munshi, S. Abel, G. Batugedara, M. Gupta, X. M. Lu, T. Lenz, S. Chakravarty, , C. Ben Mamoun

This study decodes the nuclear genome of Babesia duncani, identifies virulence factors and drug targets, and discovers potent inhibitors for treating babesiosis.

bioRxiv · May 9, 2022Microbiology

Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection

J. E. Chiu, I. Renard, A. Chattopadhyay Pal, P. Singh, P. Vydyam, J. Thekkiniath, M. Kumar, S. Gihaz, S. Pou, R. W. Winter, R. Dodean, A. Nilsen, M. K. Riscoe, J. S. Doggett, C. Ben Mamoun

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

bioRxiv · Mar 31, 2021Microbiology

The maternal foam plug constitutes a reservoir for the desert locust's bacterial symbionts

O. Lavy, U. Gophna, A. Ayali, S. Gihaz, A. Fishman, E. Gefen

The paper identifies the maternal foam plug as a medium for vertical transmission of locust gut bacteria, revealing its role in symbiont inheritance and swarm formation.

bioRxiv · Sep 15, 2020Ecology