Author

J. Toombs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. T. Dominguez· 1 shared A. Taylor· 1 shared A. Wellstein· 1 shared B. T. Selvaraj· 1 shared C. Browne· 1 shared C. Lewis· 1 shared C. Liu· 1 shared C. N. Svendsen· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. T. Dominguez

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Author profile →

3 papers

Recent·Most cited

Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

D. Ganguly, M. O. Schmidt, M. Coleman, T.-V. Ngo, N. Sorrelle, A. T. Dominguez, J. Toombs, C. Lewis, Y. Fang, F. V. Mora, D. Gallego-Ortega, A. Wellstein, R. A. Brekken

This study identifies pleiotrophin as a driver of a pro-metastatic immune niche in breast cancer, showing its role in immune suppression and metastasis, and highlights its potential as a therapeutic target.

bioRxiv · May 2, 2022Cancer Biology

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

J. Toombs, L. Panther, L. Ornelas, C. Liu, E. Gomez, R. Martinibanez, S. R. Cox, S. J. Ritchie, S. E. Harris, A. Taylor, P. Redmond, T. C. Russ, L. Murphy, J. D. Cooper, K. Burr, , D. Sareen

The paper generates 24 induced pluripotent stem cell lines from members of the Lothian Birth Cohort 1936 to study cognitive ageing and neurodegenerative disease resilience.

bioRxiv · Feb 5, 2020Cell Biology

Cancer cell exosomes can initiate malignant cell transformation

K. Stefanius, K. Severage, M. de Souza Santos, J. Toombs, H. Gray, S. Chimalapati, M. S. Kim, R. Brekken, K. Orth

Cancer cell exosomes initiate malignant cell transformation by causing random genetic changes in recipient cells, leading to aggressive tumor growth in mice.

bioRxiv · Jul 3, 2018 · PreprintCancer Biology