J. X. Wang

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

Endogenous sterol synthesis is dispensable for Trypanosoma cruzi epimastigote growth but not stress tolerance

This study shows that CYP51 is not essential for T. cruzi epimastigote growth but is required for stress tolerance, as its disruption leads to sterol auxotrophy and sensitivity to elevated temperature.

Nurturing Diversity and Inclusion in AI in Biomedicine through a Virtual Summer Program for High School Students

The paper describes a virtual summer program for high school students aimed at increasing diversity in AI through biomedical education, showing improved knowledge and engagement in AI concepts.

Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

This study shows that glutamine metabolism affects azole susceptibility in Trypanosoma cruzi amastigotes by influencing sterol biosynthesis and metabolic intermediates.

Direct RNA sequencing reveals structural differences between transcript isoforms

This study introduces PORE-cupine, a method combining structure probing and nanopore sequencing to detect RNA secondary structures, revealing isoform-specific structural differences and their impact on translation efficiency.

The L-alanosine gene cluster encodes a pathway for diazeniumdiolate biosynthesis

This paper identifies a gene cluster in Streptomyces alanosinicus responsible for diazeniumdiolate biosynthesis and characterizes the pathway's key enzymes and intermediates.

Toll-like receptor 2 stimulation augments esophageal epithelial barrier integrity

This study shows that TLR2 stimulation enhances esophageal epithelial barrier function by increasing tight junction protein expression and altering chromatin structure.