Author

L. Brückner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. G. Henssen· 2 shared A. Eggert· 1 shared A. Kühl· 1 shared A. M. Wengner· 1 shared B. J. He· 1 shared B. Schäfer· 1 shared B. Werner· 1 shared C. Röefzaad· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. G. Henssen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

K. L. Hung, M. G. Jones, I. T.-L. Wong, J. T. Lange, J. Luebeck, E. Scanu, B. J. He, L. Brückner, R. Li, R. C. Gonzalez, R. Schmargon, J. R. Dörr, J. A. Belk, V. Bafna, B. Werner, , H. Y. Chang

This study shows that multiple extrachromosomal DNA species are coordinately inherited in cancer cells through mitotic co-segregation, enabling oncogene cooperation and guiding therapeutic strategies.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

F. F. Pusch, H. Dorado Garcia, R. Xu, D. Gürgen, Y. Bei, L. Brückner, C. Röefzaad, J. von Stebut, V. Bardinet, M. d. R. Chamorro Gonzalez, A. Eggert, J. H. Schulte, P. Hundsdörfer, G. Seifert, K. Haase, , A. G. Henssen

This paper evaluates elimusertib's preclinical efficacy in pediatric solid tumor models, finding it outperforms standard chemotherapy, especially in alveolar rhabdomysarcoma.

bioRxiv · Nov 10, 2022 · PreprintCancer Biology