Z. Sheng

Increased interaction between connexin43 and microtubules is critical for glioblastoma stem-like cell maintenance and tumorigenicity.

This study identifies a novel peptide, JM2, that disrupts Cx43-microtubule interaction in GBM stem-like cells, reducing their survival and tumorigenicity.

Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2

The paper analyzes the receptor affinity and antibody evasion properties of SARS-CoV-2 BA.2.75 subvariants, identifying two evolutionary pathways and three mutations that influence their virological features.

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

Resistance of SARS-CoV-2 Omicron Subvariant BA.4.6 to Antibody Neutralization

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

Structural basis for antibody resistance to SARS-CoV-2 omicron variant

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

Potential Linkage between Toxoplasma gondii Infection and Physical Education Scores of College Students

The study examines the link between Toxoplasma gondii infection and physical education scores in college students, finding higher scores in infected students in specific sports.

Connexin 43 confers chemoresistance through activating PI3K

This study identifies Cx43's role in glioblastoma chemoresistance by activating PI3K signaling, and shows that targeting Cx43 and PI3K{beta} restores temozolomide sensitivity.

Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

NatB modulates Rb mutant cell death and tumor growth by regulating EGFR/MAPK signaling through the N-end rule pathways

This study shows NatB regulates Rb mutant cell survival and tumor growth by modulating EGFR/MAPK signaling through N-end rule pathways by affecting protein stability.

The Biological Evaluation of Fusidic Acid and Its Hydrogenation Derivative as Antimicrobial and Anti-inflammatory Agents

This study evaluates fusidic acid and its hydrogenation derivative for antimicrobial and anti-inflammatory effects against Gram-positive bacteria and in a mouse model.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.