Author

J. Zook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

P. Fromme· 3 shared A. Singharoy· 2 shared A. Barty· 1 shared A. Katz· 1 shared A. Mondal· 1 shared A. Perez· 1 shared C. Gupta· 1 shared C. Kupitz· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

P. Fromme

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Author profile →

3 papers

Recent·Most cited

Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma

R. J. Boyd, T. Olson, J. Zook, M. Aceves, D. Stein, W.-H. Lin, F. Craciunescu, D. T. Hansen, P. Z. Anastasiadis, A. Singharoy, P. Fromme

This study characterizes human Syx, a RhoGEF involved in glioblastoma, and performs computational simulations to elucidate its structure and allosteric regulation.

bioRxiv · Aug 26, 2021Biochemistry

CryoFold: Ab-initio structure determination from electron density maps using molecular dynamics

M. Shekhar, G. Terashi, C. Gupta, D. Sarkar, G. Debussche, N. Sisco, J. Nguyen, A. Mondal, J. Zook, J. Vant, P. Fromme, W. D. van Horn, D. Kihara, E. Tajkhorshid, K. Dill, , A. Singharoy

CryoFold determines protein structures from electron density maps using molecular dynamics and physical knowledge, producing ensembles of low-energy conformations validated experimentally.

bioRxiv · Aug 3, 2020 · PreprintBiophysics

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

J. Olmos, S. Pandey, J. M. Martin-Garcia, G. Calvey, A. Katz, J. Knoska, C. Kupitz, M. S. Hunter, M. Liang, D. Oberthuer, O. Yefanov, M. Wiedorn, M. Heymann, M. Holl, K. Pande, , Our

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

bioRxiv · Jan 18, 2018Biophysics