Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
I. Yapici, E. H. Dao, S. Yokoi, E. Destan, E. Ayan, A. Shafiei Kamel, F. B. Ertem, C. Kulakman, M. Yilmaz, B. Tosun, H. Ciftci, A. Kepceoglu, J. A. Johnson, O. Guven, A. Ergul, , H. DeMirci
This study uses 4D crystallography to capture transient dynamics of IF1 binding to the 30S ribosomal subunit, revealing allostery and interactions during translation initiation.
bioRxiv · Oct 27, 2023 · PreprintBiophysics
B. Tosun, Y. Rao, E. Destan, E. H. Dao, F. B. Ertem, M. Yilmaz, I. Yapici, M. Gul, E. Ayan, J. A. Johnson, A. Shafiei, C. Kulakman, B. Hayes, M. Liang, C. H. Yoon, , H. DeMirci
This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.
bioRxiv · Oct 24, 2023 · PreprintBiophysics
N. Smith, M. Dasgupta, D. C. Wych, C. Dolamore, R. G. Sierra, S. Lisova, D. Marchany-Rivera, A. E. Cohen, S. Boutet, M. S. Hunter, C. Kupitz, F. Poitevin, F. R. Moss, A. S. Brewster, N. K. Sauter, , M. A. Wilson
The paper uses XFEL crystallography to observe conformational changes in an enzyme during catalysis, revealing ionization-linked dynamics that control catalytic activity.
bioRxiv · Aug 15, 2023Biochemistry
K. A. Zielinski, S. Sui, S. A. Pabit, D. A. Rivera, T. Wang, Q. Hu, M. M. Kashipathy, S. Lisova, C. B. Schaffer, V. Mariani, M. S. Hunter, C. J. Kupitz, F. R. Moss, F. P. Poitevin, T. D. Grant, L. Pollack
This paper reveals RNA structures and dynamics at near-atomic resolution using x-ray free electron lasers, showing how RNA folds through intermediate states and forms triplexes.
bioRxiv · May 24, 2023Biophysics
S.-R. Yeh, I. Ishigami, D. L. Rousseau, S. Carbajo, N. Zatsepin, J. Coe, M. Hikita, M. H. Seaberg, R. G. Sierra, M. S. Hunter, P. Fromme, R. Fromme, G. Nelson, T. Grant, S. Basu, C. Conrad
The paper detects a geminate photoproduct of bovine cytochrome c oxidase using time-resolved serial femtosecond crystallography, revealing the ligand dissociation trajectory and protein dynamics.
bioRxiv · May 8, 2023Biophysics
H. Demirci, Y. Rao, G. M. Stoffel, B. Vögeli, K. Schell, A. Gomez, A. Batyuk, C. Gati, R. G. Sierra, M. S. Hunter, E. H. Dao, H. I. Ciftci, B. Hayes, F. Poitevin, P. Li, , S. Wakatsuki
This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.
bioRxiv · Feb 23, 2022 · PreprintBiophysics
E. Ayan, B. Yuksel, E. Destan, F. B. Ertem, G. Yildirim, M. Eren, O. M. Yefanov, A. Barty, A. Tolstikova, G. K. Ketawala, S. Botha, E. H. Dao, B. Hayes, M. Liang, M. H. Seaberg, , H. DeMirci
The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.
bioRxiv · Sep 23, 2021Biophysics
S. Durdagi, C. Dag, B. Dogan, M. Yigin, T. Avsar, C. Buyukdag, I. Erol, F. B. Ertem, S. Calis, G. Yildirim, M. Orhan, O. Guven, B. Aksoydan, E. Destan, K. Sahin, , Sn
The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.
bioRxiv · Sep 9, 2020Biophysics
M. E. O'Sullivan, F. Poitevin, R. G. Sierra, C. Gati, E. H. Dao, Y. Rao, F. Aksit, H. Ciftci, N. Corsepius, R. Greenhouse, B. Hayes, M. S. Hunter, M. Liang, A. McGurk, P. Mbgam, , H. DeMirci
This study examines aminoglycoside interactions with the bacterial 30S ribosome at ambient and cryogenic temperatures, revealing temperature-sensitive conformational changes and new structural states.
bioRxiv · Jul 19, 2018Biophysics
E. H. Dao, F. Poitevin, R. G. Sierra, C. Gati, Y. Rao, H. I. Ciftci, F. Aksit, A. McGurk, T. Obrinski, P. Mgbam, B. Hayes, C. de Lichtenberg, F. Pardo-Avila, N. Corsepius, L. Zhang, , H. DeMirci
The paper reports an ambient-temperature X-ray crystal structure of the Thermus thermophilus 30S ribosomal decoding complex, showing consistency with cryogenic structures but with minor conformational variations.
bioRxiv · Mar 9, 2018Biophysics
J. Olmos, S. Pandey, J. M. Martin-Garcia, G. Calvey, A. Katz, J. Knoska, C. Kupitz, M. S. Hunter, M. Liang, D. Oberthuer, O. Yefanov, M. Wiedorn, M. Heymann, M. Holl, K. Pande, , Our
This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.
bioRxiv · Jan 18, 2018Biophysics