Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
D.-S. Baek, Y.-J. Kim, W. Li, B. J. Macatangay, J. C. Cyktor, M. G. Hines, J. W. Mellors, D. S. Dimitrov
The paper discovers and evaluates two fully human antibodies that inhibit NKG2A, an inhibitory receptor on NK and CD8+ T cells, enhancing anti-cancer immune responses.
bioRxiv · May 18, 2022 · PreprintImmunology
Z. Sun, X. Chu, C. Adams, T. V. Ilina, C. Chen, D. Jelev, R. Ishima, W. Li, J. W. Mellors, G. Calero, D. S. Dimitrov
The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.
bioRxiv · Apr 7, 2022 · PreprintCancer Biology
C. Chen, J. W. Saville, M. M. Marti, A. Schaefer, M. H. Cheng, D. Mannar, X. Zhu, A. M. Berezuk, A. Banerjee, M. D. Sobolewski, A. Kim, B. R. Treat, P. M. Da Silva Castanha, N. Enick, K. D. McCormick, , W. Li
This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.
bioRxiv · Feb 18, 2022 · PreprintImmunology
D. Mannar, J. W. Saville, X. Zhu, S. S. Srivastava, A. M. Berezuk, S. Zhou, K. Tuttle, A. Kim, W. Li, D. S. Dimitrov, S. Subramaniam
The paper analyzes mutations in the SARS-CoV-2 receptor binding domain to understand their effects on ACE2 and antibody binding in variants of concern.
Cell Reports · Dec 1, 2021Peer-reviewedBiochemistry
Z. Sun, A. Kim, M. D. Sobolewski, N. Enick, C. Chen, C. Adams, J. L. Jacobs, K. D. McCormick, J. W. Mellors, D. S. Dimitrov, W. Li
The paper evaluates an antibody domain's ability to neutralize SARS-CoV-2 variants with mutations in the RBD, showing it neutralizes the triple mutation variant but not others.
bioRxiv · Mar 22, 2021 · PreprintImmunology
X. Zhu, D. Mannar, S. S. Srivastava, A. Berezuk, J.-P. Demers, J. Saville, K. Leopold, W. Li, D. S. Dimitrov, K. Tuttle, S. Zhou, S. Chittori, S. Subramaniam
The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.
bioRxiv · Jan 11, 2021 · PreprintBiophysics
W. Li, A. Drelich, D. R. Martinez, L. E. Gralinski, C. Chen, Z. Sun, A. Schäfer, S. R. Leist, X. Liu, D. V. Zhelev, L. Zhang, E. L. Peterson, A. Conard, J. W. Mellors, C.-T. Tseng, , D. S. Dimitrov
This study rapidly identifies a potent human monoclonal antibody against SARS-CoV-2 that neutralizes the virus in animal models and shows promise for therapeutic use.
bioRxiv · May 13, 2020 · PreprintMicrobiology