Author

S. Chittori

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Organism:virus· 1

Frequent Co-Authors

A. Berezuk· 2 shared K. Tuttle· 2 shared S. Subramaniam· 2 shared X. Zhu· 2 shared B. Caffrey· 1 shared D. Mannar· 1 shared D. S. Dimitrov· 1 shared J. Saville· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

A. Berezuk

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2 papers

Recent·Most cited

Cryo-EM reveals disrupted human p97 allosteric activation by disease mutations and inhibitor binding

B. Caffrey, X. Zhu, A. Berezuk, K. Tuttle, S. Chittori, S. Subramaniam

This study uses cryo-EM to analyze disease mutations and inhibitor binding in p97, revealing how these affect allosteric activation and provide insights into their mechanistic link to dysfunction.

bioRxiv · Aug 10, 2021Biochemistry

Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies

X. Zhu, D. Mannar, S. S. Srivastava, A. Berezuk, J.-P. Demers, J. Saville, K. Leopold, W. Li, D. S. Dimitrov, K. Tuttle, S. Zhou, S. Chittori, S. Subramaniam

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.

bioRxiv · Jan 11, 2021 · PreprintBiophysics