Author

K. Leopold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Mannar· 3 shared S. Subramaniam· 3 shared A. Berezuk· 1 shared A. Hutchinson· 1 shared A. Seitova· 1 shared B. J. Fraser· 1 shared C. H. Arrowsmith· 1 shared D. Kwon· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

D. Mannar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

B. J. Fraser, S. Beldar, A. Seitova, A. Hutchinson, D. Mannar, Y. Li, D. Kwon, R. Tan, R. P. Wilson, K. Leopold, S. Subramaniam, L. Halabelian, C. H. Arrowsmith, F. Benard

This study characterizes the structure and function of TMPRSS2, a protease involved in SARS-CoV-2 activation, and identifies features for developing selective inhibitors.

bioRxiv · Jun 23, 2021Biochemistry

Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies

X. Zhu, D. Mannar, S. S. Srivastava, A. Berezuk, J.-P. Demers, J. Saville, K. Leopold, W. Li, D. S. Dimitrov, K. Tuttle, S. Zhou, S. Chittori, S. Subramaniam

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.

bioRxiv · Jan 11, 2021 · PreprintBiophysics

Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry

D. Mannar, K. Leopold, S. Subramaniam

This study shows that two anti-HIV-1 antibodies bind SARS-CoV-2 spike glycoprotein but do not neutralize it or mediate ADE.

bioRxiv · Jan 3, 2021Microbiology