Author

J.-P. Laverdure

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Perreault· 4 shared C. Durette· 3 shared G. Ehx· 3 shared J.-D. Larouche· 3 shared K. Vincent· 3 shared P. Thibault· 3 shared S. Lemieux· 3 shared A. Trofimov· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

C. Perreault

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Author profile →

4 papers

Recent·Most cited

Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia

N. Noronha, C. Durette, B. E Silva, J. Courtois, J. Humeau, A. Sauvat, M.-P. Hardy, K. Vincent, J.-P. Laverdure, J. Lanoix, F. Baron, P. Thibault, C. Perreault, G. Ehx

This study shows that 5-azacytidine induces endogenous retroelement transcripts in AML cells, which are degraded by autophagy and not presented as MHC-I peptides, and that autophagy inhibition enhances immune responses.

Leukemia · Apr 16, 2024Peer-reviewedImmunology

Transposable elements regulate thymus development and function

J.-D. Larouche, C. M. Laumont, A. Trofimov, K. Vincent, L. Hesnard, S. Brochu, C. Cote, J. Humeau, E. Bonneil, J. Lanoix, C. Durette, P. Gendron, J.-P. Laverdure, E. R. Richie, S. Lemieux, , C. Perreault

This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.

bioRxiv · Jul 12, 2023Immunology

BamQuery: a proteogenomic tool for the genome-wide exploration of the immunopeptidome

M. V. Ruiz Cuevas, M.-P. Hardy, J.-D. Larouche, A. Apavaloaei, E. Kina, K. Vincent, P. Gendron, J.-P. Laverdure, C. Durette, P. Thibault, S. Lemieux, C. Perreault, G. Ehx

BamQuery quantifies MAPs from various genomic regions in bulk and single-cell RNA-seq data, revealing non-canonical sources of tumor antigens and viral peptides.

bioRxiv · Oct 7, 2022Immunology

Two types of human TCR differentially regulate reactivity to self and non-self antigens

A. Trofimov, P. Brouillard, J.-D. Larouche, J. Seguin, J.-P. Laverdure, A. Brasey, G. Ehx, D.-C. Roy, L. Busque, S. Lachance, S. Lemieux, C. Perreault

The paper identifies two distinct TCR types in humans, differing in origin, function, and reactivity to self and non-self antigens, with implications for immunity and disease.

bioRxiv · Apr 27, 2022Immunology