Author

K. Vincent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Durette· 3 shared C. Perreault· 3 shared J.-P. Laverdure· 3 shared P. Thibault· 3 shared G. Ehx· 2 shared J. Humeau· 2 shared J. Lanoix· 2 shared J.-D. Larouche· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

C. Durette

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Successful Cardiac Resynchronization Therapy Reduces Negative Septal Work in Patient-Specific Models of Dyssynchronous Heart Failure

A. Craine, A. Krishnamurthy, C. T. Villongco, K. Vincent, D. E. Krummen, S. M. Narayan, R. C. P. Kerckhoffs, J. H. Omens, F. Contijoch, A. D. McCulloch

This study uses patient-specific models to show that CRT improves myocardial work efficiency and reverse remodeling in DHF by reducing negative work in early-activated regions.

bioRxiv · May 13, 2024Bioengineering

Transposable elements regulate thymus development and function

J.-D. Larouche, C. M. Laumont, A. Trofimov, K. Vincent, L. Hesnard, S. Brochu, C. Cote, J. Humeau, E. Bonneil, J. Lanoix, C. Durette, P. Gendron, J.-P. Laverdure, E. R. Richie, S. Lemieux, , C. Perreault

This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.

bioRxiv · Jul 12, 2023Immunology

Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia

N. Noronha, C. Durette, B. E Silva, J. Courtois, J. Humeau, A. Sauvat, M.-P. Hardy, K. Vincent, J.-P. Laverdure, J. Lanoix, F. Baron, P. Thibault, C. Perreault, G. Ehx

This study shows that 5-azacytidine induces endogenous retroelement transcripts in AML cells, which are degraded by autophagy and not presented as MHC-I peptides, and that autophagy inhibition enhances immune responses.

bioRxiv · Dec 2, 2022Immunology

Energy extraction from air: structural basis of atmospheric hydrogen oxidation

R. Grinter, A. Kropp, H. Venugopal, M. Senger, J. Badley, P. Cabotaje, S. T. Stripp, C. Barlow, M. J. Belousoff, G. M. Cook, K. Vincent, R. B. Schittenhelm, S. Khalid, G. Berggren, C. Greening

This paper determines the structure of a mycobacterial hydrogenase and explains how it selectively oxidizes atmospheric H2 while avoiding O2, enabling energy extraction from air.

bioRxiv · Oct 9, 2022 · PreprintBiochemistry

BamQuery: a proteogenomic tool for the genome-wide exploration of the immunopeptidome

M. V. Ruiz Cuevas, M.-P. Hardy, J.-D. Larouche, A. Apavaloaei, E. Kina, K. Vincent, P. Gendron, J.-P. Laverdure, C. Durette, P. Thibault, S. Lemieux, C. Perreault, G. Ehx

BamQuery quantifies MAPs from various genomic regions in bulk and single-cell RNA-seq data, revealing non-canonical sources of tumor antigens and viral peptides.

bioRxiv · Oct 7, 2022Immunology

Hexavalent Sperm-Binding IgG Antibody Released from Self-Dissolving Vaginal Film Enables Potent, On-Demand Non-Hormonal Female Contraception

B. Shrestha, K. Vincent, A. Schaefer, Y. Zhu, G. Vargas, M. Motamedi, K. Swope, J. Morton, C. Simpson, H. Pham, M. B. Brennan, M. H. Pauly, L. Zeitlin, B. Bratcher, K. J. Whaley, , S. K. Lai

This paper develops a non-hormonal contraceptive method using a hexavalent sperm-binding antibody delivered via a dissolving vaginal film, showing potent sperm inhibition in sheep.

bioRxiv · Apr 19, 2021 · PreprintBioengineering