Author

S. Lemieux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

C. Perreault· 3 shared J.-D. Larouche· 3 shared J.-P. Laverdure· 3 shared P. Thibault· 3 shared A. Trofimov· 2 shared C. Durette· 2 shared G. Ehx· 2 shared K. Vincent· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersImmunology

C. Perreault

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transposable elements regulate thymus development and function

J.-D. Larouche, C. M. Laumont, A. Trofimov, K. Vincent, L. Hesnard, S. Brochu, C. Cote, J. Humeau, E. Bonneil, J. Lanoix, C. Durette, P. Gendron, J.-P. Laverdure, E. R. Richie, S. Lemieux, , C. Perreault

This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.

bioRxiv · Jul 12, 2023Immunology

BamQuery: a proteogenomic tool for the genome-wide exploration of the immunopeptidome

M. V. Ruiz Cuevas, M.-P. Hardy, J.-D. Larouche, A. Apavaloaei, E. Kina, K. Vincent, P. Gendron, J.-P. Laverdure, C. Durette, P. Thibault, S. Lemieux, C. Perreault, G. Ehx

BamQuery quantifies MAPs from various genomic regions in bulk and single-cell RNA-seq data, revealing non-canonical sources of tumor antigens and viral peptides.

bioRxiv · Oct 7, 2022Immunology

Two types of human TCR differentially regulate reactivity to self and non-self antigens

A. Trofimov, P. Brouillard, J.-D. Larouche, J. Seguin, J.-P. Laverdure, A. Brasey, G. Ehx, D.-C. Roy, L. Busque, S. Lachance, S. Lemieux, C. Perreault

The paper identifies two distinct TCR types in humans, differing in origin, function, and reactivity to self and non-self antigens, with implications for immunity and disease.

bioRxiv · Apr 27, 2022Immunology

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

I. Baccelli, Y. Gareau, B. Lehnertz, S. Gingras, J.-F. Spinella, A. Beautrait, S. Corneau, N. Mayotte, I. Boivin, S. Girard, T. MacRae, M. Frechette, K. Leveille, J. Krosl, C. Thiollier, , G. Sauvageau

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.

bioRxiv · Jan 15, 2019 · PreprintCancer Biology