Author

J.-S. Driouich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Research Focus:benchmarking· 1 Assay:metagenomics· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

A. Nougairede· 8 shared X. de Lamballerie· 7 shared F. Touret· 6 shared M. Cochin· 5 shared G. Moureau· 4 shared C. Solas· 3 shared G. Piorkowski· 3 shared K. Barthelemy· 3 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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8 shared papersMicrobiology

A. Nougairede

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

In vivo rescue of arboviruses directly from subgenomic DNA fragments

M. Cochin, J.-S. Driouich, G. Moureau, G. Piorkowski, X. N. de Lamballerie, A. Nougairede

The paper demonstrates an in vivo method to generate arboviruses from subgenomic DNA fragments, achieving 100% infection rate in mice with optimized electroporation parameters.

bioRxiv · Jan 17, 2024 · PreprintMicrobiology

Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains

H. S. Bouzidi, J.-S. Driouich, R. Klitting, O. Bernadin, G. Piorkowski, R. Amaral, L. Fraisse, C. E. Mowbray, I. Scandale, F. Escudie, E. Chatelain, X. de Lamballerie, A. Nougairede, F. Touret

The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.

bioRxiv · Nov 22, 2023Microbiology

Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model

J.-S. Driouich, O. Bernadin, F. Touret, X. de Lamballerie, A. Nougairede

This study evaluates Sotrovimab's antiviral activity against BQ.1.1 and XBB.1 Omicron variants in a hamster model, finding retained but reduced efficacy compared to earlier variants.

bioRxiv · Jan 4, 2023Microbiology

Pre-clinical evaluation of antiviral activity of nitazoxanide against Sars-CoV-2

J.-S. Driouich, M. Cochin, F. Touret, P.-R. Petit, M. Gilles, G. Moureau, K. Barthelemy, C. Laprie, T. Wattanakul, P. Chotsiri, R. M. Hoglund, J. Tarning, F. Escudie, I. Scandale, E. Chatelain, , A. Nougairede

This study evaluates nitazoxanide's antiviral activity against SARS-CoV-2 in vitro and in vivo, finding that its standard dosage is ineffective due to insufficient drug concentration in target organs.

bioRxiv · Dec 17, 2021Pathology

Replicative fitness SARS-CoV-2 20I/501Y.V1 variant in a human reconstituted bronchial epithelium

F. Touret, L. Luciani, C. Baronti, M. Cochin, J.-S. Driouich, M. Gilles, L. Thirion, A. Nougairede, X. de Lamballerie

This study compares the replication efficiency of the SARS-CoV-2 20I/501Y.V1 variant with an ancestral strain in human bronchial epithelium models, finding the variant outcompetes the ancestral strain in competition experiments.

bioRxiv · Mar 22, 2021Microbiology

Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2

F. Touret, J.-S. Driouich, M. Cochin, P. R. Petit, M. Gilles, K. Barthelemy, G. Moureau, F.-X. MAHON, D. Malvy, C. Solas, X. de Lamballerie, A. Nougairede

This study evaluates Imatinib's antiviral potential against SARS-CoV-2 in vitro and in vivo, finding it ineffective in key models despite plasma and lung concentrations.

bioRxiv · Nov 17, 2020Microbiology

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

J.-S. Driouich, M. Cochin, G. Lingas, G. Moureau, F. Touret, P.-R. Petit, G. Piorkowski, K. Barthelemy, B. Coutard, J. Guedj, X. de Lamballerie, C. Solas, A. Nougairede

This study evaluates favipiravir's antiviral efficacy against SARS-CoV-2 in a Syrian hamster model, showing dose-dependent reduction of viral titers and disease symptoms.

bioRxiv · Jul 7, 2020Microbiology

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

L. Eyer, A. Nougairede, M. Uhlirova, J.-S. Driouich, D. Zouharova, J. J. Valdes, J. Haviernik, E. A. Gould, E. De Clercq, X. de Lamballerie, D. Ruzek

This paper identifies an E460D substitution in TBEV RdRp that confers resistance to Galidesivir and attenuates the virus in mice.

bioRxiv · Feb 28, 2019Microbiology