B. Coutard

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

The paper discusses the implications of spike-glycoprotein processing by Furin and TMPRSS2 on SARS-CoV-2 infectivity and cell entry, but the manuscript has been withdrawn.

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion

This study investigates the roles of Furin and TMPRSS2 in SARS-CoV-2 spike protein processing and viral entry, showing their synergistic effects and suggesting combined inhibitors as antivirals.

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

This study evaluates favipiravir's antiviral efficacy against SARS-CoV-2 in a Syrian hamster model, showing dose-dependent reduction of viral titers and disease symptoms.

Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

This study shows Favipiravir inhibits SARS-CoV-2 by targeting its RNA polymerase through chain termination, slowed synthesis, and mutagenesis.

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

This study screens an FDA-approved chemical library to identify potential inhibitors of SARS-CoV-2 replication in vitro, finding several compounds with antiviral potency.