J. Guedj

Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection

This study uses mathematical modeling of SIV-infected macaques to show that early CD8 T-cell suppressive capacity predicts natural control of infection.

Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.

This study examines how SARS-CoV-2 variants of concern affect viral dynamics in non-human primates, finding that most variants escape immune responses, with delta and omicron showing significant differences in viral production rates.

Combination of in vivo phage therapy data with in silico model highlights key parameters for treatment efficacy

The paper combines in vivo phage therapy data with an in silico model to identify key parameters affecting treatment efficacy in bacterial pneumonia.

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

This study evaluates favipiravir's antiviral efficacy against SARS-CoV-2 in a Syrian hamster model, showing dose-dependent reduction of viral titers and disease symptoms.

Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

Modeling SIV dynamics in natural controller macaques shows viral control is driven by early cytotoxic T-cell response and reveals distinct infected cell compartments with different turnover rates.

Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study

This study shows that optimal maturation of SIV-specific CD8+ T-cells correlates with natural control of SIV infection in macaques, with controllers developing more potent antiviral responses over time.