Author

J.-W. E. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. N. Sarkaria· 3 shared B. Harley· 2 shared J. C. Lumibao· 2 shared R. Gaskins· 2 shared S. Pedron· 2 shared A. J. Steelman· 1 shared A. Ruiz· 1 shared A. Steelman· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBioengineering

J. N. Sarkaria

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Author profile →

4 papers

Recent·Most cited

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance

J. C. Lumibao, P. Haak, V. L. Kolossov, J.-W. E. Chen, J. Stutchman, A. Ruiz, M. Sivaguru, J. N. Sarkaria, B. C. Harley, A. J. Steelman, R. Gaskins

This study shows CHCHD2 promotes glioblastoma cell proliferation, hypoxia-induced invasion, and drug resistance by affecting mitochondrial function and nuclear signaling.

International Journal of Oncology · Aug 25, 2023Peer-reviewedCancer Biology

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model

J.-W. E. Chen, J. C. Lumibao, S. Leary, J. Sarkaria, A. Steelman, R. Gaskins, B. Harley

This study shows that microglia reduce glioblastoma invasion in a 3D hydrogel model through paracrine signaling, identified via secretome and transcriptome analysis.

bioRxiv · Aug 6, 2020Cancer Biology

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

S. Pedron, G. L. Wolter, J.-W. E. Chen, S. E. Laken, J. N. Sarkaria, B. A. Harley

This study uses a 3D hydrogel platform to investigate how extracellular matrix signals affect erlotinib efficacy in patient-derived glioblastoma cells with different EGFR mutations.

bioRxiv · Jul 12, 2019Bioengineering

Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior

J.-W. E. Chen, S. Pedron, P. Shyu, Y. Hu, J. N. Sarkaria, B. Harley

This study investigates how different molecular weights of hyaluronic acid in hydrogels affect the invasive behavior of glioblastoma cells.

bioRxiv · Apr 13, 2018Bioengineering