B. Harley

Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties

This study investigates how glioblastoma cells use hyaluronan to support proliferation and resistance, proposing a combination treatment targeting HA synthesis and degradation.

Acquired temozolomide resistance instructs patterns of glioblastoma behavior in gelatin hydrogels

This paper develops a 3D hydrogel model to study how acquired temozolomide resistance affects glioblastoma cell behavior, showing changes in drug sensitivity, invasion, and cytokine production.

DONOR VARIABILITY IN HUMAN MESENCHYMAL STEM CELL OSTEOGENIC RESPONSE AS A FUNCTION OF PASSAGE CONDITIONS AND DONOR SEX

This study investigates how donor sex and passage number affect human mesenchymal stem cell osteogenic response in mineralized collagen scaffolds, finding sex-based differences in proliferation and osteogenic potential.

Cell Chirality of Micropatterned Endometrial Microvascular Endothelial Cells

This study investigates how extracellular matrix properties and hormones influence chirality in endometrial endothelial cells and their vascular networks.

Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial

This paper develops a generative design method to create tunable composite biomaterials by combining Voronoi foams with collagen scaffolds for better mechanical performance and conformal fitting in bone defect repair.

Endometrial decidualization status modulates endometrial perivascular complexity and trophoblast outgrowth in gelatin hydrogels

This study creates an artificial endometrial perivascular niche in hydrogels to study how decidualization affects vessel complexity and trophoblast outgrowth.

Pericytes and Astrocytes Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model

This study develops an engineered brain perivascular niche model to investigate how pericytes and astrocytes influence GBM tumor cell invasion, proliferation, and therapeutic response.

Soluble extracts from amnion and chorion membranes improve hMSC osteogenic response in a mineralized collagen scaffold

This study shows that adding soluble extracts from amnion and chorion membranes to mineralized collagen scaffolds enhances hMSC osteogenic activity and mineral deposition.

The role of extracellular matrix biomolecules on endometrial epithelial cell attachment and cytokeratin 18 expression on gelatin hydrogels

This study investigates how combinations of basement membrane proteins affect endometrial epithelial cell attachment and cytokeratin 18 expression using gelatin hydrogels.

Repair of critical-size porcine craniofacial bone defects using a collagen-polycaprolactone composite biomaterial

This study evaluates a collagen-polycaprolactone composite for repairing large porcine craniofacial bone defects, showing limited bone regeneration and highlighting areas for improvement.

Glycosaminoglycan content of a mineralized collagen scaffold promotes mesenchymal stem cell secretion of factors to modulate angiogenesis and monocyte differentiation

Encapsulation and recovery of murine hematopoietic stem and progenitor cells in a thiol-crosslinked maleimide-functionalized gelatin hydrogel

This paper develops a GelMAL hydrogel for encapsulating stem cells with tunable properties and cleavable crosslinks, preserving stem cell markers.

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model

This study shows that microglia reduce glioblastoma invasion in a 3D hydrogel model through paracrine signaling, identified via secretome and transcriptome analysis.

Inclusion of a 3D-printed Hyperelastic bone mesh improves mechanical and osteogenic performance of a mineralized collagen scaffold

This study shows that adding a 3D-printed Hyperelastic Bone mesh to a mineralized collagen scaffold improves mechanical strength and osteogenic performance in bone regeneration.

Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds

This study demonstrates that sequential sequestration of growth factors in mineralized collagen scaffolds enhances their retention and controlled release, potentially improving bone healing.

Perivascular Secretome Influences Hematopoietic Stem Cell Maintenance in a Gelatin Hydrogel

This study develops a 3D gelatin hydrogel model of the perivascular niche to show that its secretome promotes HSC maintenance in vitro.

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

The paper develops mineralized collagen-amnion scaffolds that enhance osteogenesis in inflammatory conditions using porcine adipose-derived stem cells.

Tough and Tunable Scaffold-Hydrogel Composite Biomaterial for Soft-to-Hard Musculoskeletal Tissue Interfaces

The paper introduces a composite biomaterial with a tunable hydrogel interface to improve biomechanical performance at musculoskeletal tissue interfaces.

Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche

The paper identifies cytokine cocktails that enhance hematopoietic stem cell maintenance in an engineered niche using proteomic analysis and computational methods.

Anisotropic mineralized collagen scaffolds accelerate osteogenic response in a glycosaminoglycan-dependent fashion

This study shows anisotropic mineralized collagen scaffolds enhance osteogenic response in a glycosaminoglycan-dependent manner by improving bone mineral synthesis.

Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma cell number, invasion, and temozolomide resistance

Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels

The paper investigates how hypoxia-induced oxidative stress affects neuroglia, astrocyte reactivity, and myelin production using a 3D hydrogel system in a microfluidic device.

A Gelatin Hydrogel to Study Endometrial Angiogenesis and Trophoblast Invasion

This study develops a gelatin hydrogel platform to model endometrial angiogenesis and trophoblast invasion in 3D, supporting endothelial networks, epithelial layers, and hormone-responsive stromal cells.

Mesenchymal stromal cell remodeling of a gelatin hydrogel microenvironment defines an artificial hematopoietic stem cell niche

This study develops a GelMA hydrogel system with co-encapsulated MSCs to enhance HSC maintenance and quiescence through dynamic matrix remodeling and signaling balance.

Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel

This study shows that including perivascular niche cells in a hydrogel model of glioblastoma alters gene expression and reduces response to temozolomide compared to models with only tumor cells.

Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior

This study investigates how different molecular weights of hyaluronic acid in hydrogels affect the invasive behavior of glioblastoma cells.