J.-X. Feng

Bone marrow hemogenic endothelial cells contribute multilineage hematopoietic progenitors in adult mice

The paper identifies a subset of bone marrow endothelial cells in adult mice that generate hematopoietic progenitors and mature blood cells through endothelial-to-hematopoietic transition.

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

This study shows that inhibiting SHP2 in endothelial cells reduces tumor growth by damaging the tumor vasculature, independent of SHP2 effects in tumor cells.