Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth
Y. Wang, O. Salvucci, H. Ohnuki, A. D. Tran, T. Ha, J.-X. Feng, M. DiPrima, H. Kwak, D. Wang, M. Kruhlak, G. Tosato
This study shows that inhibiting SHP2 in endothelial cells reduces tumor growth by damaging the tumor vasculature, independent of SHP2 effects in tumor cells.
bioRxiv · Oct 6, 2020Cancer Biology