Soumen Paul

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The paper identifies essential protein kinases in human trophoblast development using proteomics and genomics integration, showing their roles in different cell types and suggesting potential therapeutic targets.

Arginine methyltransferase PRMT1 equipoises trophoblast development to prevent early pregnancy loss

This study identifies PRMT1 as a critical regulator of trophoblast development, showing its role in preventing early pregnancy loss through epigenetic control of stemness and differentiation.

VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment

This study identifies VGLL1 as a key regulator of trophoblast development by integrating BMP, WNT, and HIPPO signaling through chromatin remodeling and transcriptional control in human stem cells.

Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells

The paper investigates the roles of TRIM28, DNA methylation, and p53 in regulating gene and transposon expression in human embryonic and trophoblast stem cells, revealing divergent responses to genomic instability.

Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells

METTL3 shapes m6A epitranscriptomic landscape for successful human placentation

This study shows METTL3 is essential for human placentation by regulating trophoblast self-renewal and differentiation through m6A RNA modifications.

A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

GATA-regulated transcriptional program dictate cell fate equilibrium to establish the maternal-fetal exchange interface and fetal development

This study identifies GATA2 and GATA3 as critical regulators of trophoblast progenitor differentiation into syncytiotrophoblasts, essential for placental development and fetal viability.

Hippo Signaling Cofactor, WWTR1, at the Crossroads of Human Trophoblast Progenitor Self-Renewal and Differentiation.

This study identifies WWTR1 as a master regulator of human trophoblast progenitor self-renewal and differentiation, showing its role in promoting EVT differentiation and preventing STB fate.

Atypical Protein Kinase C iota (PKC{lambda}/{iota}) Ensures Mammalian Development by Establishing the Maternal-Fetal Exchange Interface

This study identifies PKCλ/ι as essential for trophoblast progenitor differentiation into syncytiotrophoblast cells during placentation in both mice and humans.

Trophoblast paracrine signaling regulates placental hematoendothelial niche

This study shows that GATA2 and GATA3 in trophoblast giant cells regulate hematopoietic-angiogenic balance in the placenta through paracrine signaling.