Purbasa Dasgupta

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The paper identifies essential protein kinases in human trophoblast development using proteomics and genomics integration, showing their roles in different cell types and suggesting potential therapeutic targets.

Arginine methyltransferase PRMT1 equipoises trophoblast development to prevent early pregnancy loss

This study identifies PRMT1 as a critical regulator of trophoblast development, showing its role in preventing early pregnancy loss through epigenetic control of stemness and differentiation.

Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells

METTL3 shapes m6A epitranscriptomic landscape for successful human placentation

This study shows METTL3 is essential for human placentation by regulating trophoblast self-renewal and differentiation through m6A RNA modifications.

A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta

The paper shows that parietal trophoblast giant cells regulate hematopoietic stem cell development in the placenta through paracrine signaling.

GATA-regulated transcriptional program dictate cell fate equilibrium to establish the maternal-fetal exchange interface and fetal development

This study identifies GATA2 and GATA3 as critical regulators of trophoblast progenitor differentiation into syncytiotrophoblasts, essential for placental development and fetal viability.

Germline protein, Cup, non-cell autonomously limits migratory cell fate in Drosophila oogenesis.

The paper shows that the germline protein Cup non-cell autonomously restricts JAK-STAT activation in Drosophila follicle cells, influencing border cell fate through Notch signaling.