Revised Mechanism of Hydroxyurea Induced Cell Cycle Arrest and an Improved Alternative
Alisa E. Shaw, Mattias N. Mihelich, Jackson Whitted, Hannah J. Reitman, Adam J. Timmerman, Muhammad Tehseen, Samir M. Hamdan, Grant D. Schauer
This paper revises the mechanism of hydroxyurea-induced cell cycle arrest in yeast, showing it is ROS-mediated rather than Mrc1-dependent, and introduces an improved alternative to HU called RNR-deg.
Proceedings of the National Academy of Sciences · Oct 7, 2024Peer-reviewedBiochemistry