Protein-Like Polymer for Inhibition of Tau Fibril Propagation in Human-Derived Models of Neurodegeneration
Andrew P. Longhini, Mara A. Fattah, Julia Sala‐Jarque, Austin DuBose, Erica Keane Rivera, Olivia Sclafani, Jessica Zhou, Jacqueline E Anatot, Matthew P. Thompson, Matthew T. Unger, Emily R. Beckett, Colby Fagan, Dylan Nakamura, Richard I. Morimoto, Songi Han, , Kenneth S. Kosik
This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.
bioRxiv · Feb 2, 2025 · PreprintNeuroscience