Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation
Ahmed M. Elshazly, Nayyerehalsadat Hosseini, Janakiram Vangala, Shanwei Shen, Victoria L. Neely, Xiaoyan Hu, Piyusha P. Pagare, Hisashi Harada, Steven Grant, Senthil K. Radhakrishnan
This paper shows that combining proteasome inhibitors with lysosome-targeted degradation enhances cancer cell death by exploiting an adaptive autophagy response.
Cell Death and Disease · May 11, 2026Peer-reviewedBiochemistry