Author

Jane E. Dorweiler

Marquette University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Anita L. ManogaraniD· 4 shared Adam KnieriD· 2 shared Claire M. Radtke· 2 shared Hannah E. BuchholziD· 2 shared Sean A. MartiniD· 2 shared Brett T. Wisniewski· 1 shared Derek C. ProsseriD· 1 shared Douglas R. Lyke· 1 shared

Activity by Year

2017-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

Anita L. ManogaranORCID

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Author profile →

4 papers

Recent·Most cited

Intracellular aggregation of the transthyretin protein is limited by Hsp70 chaperones

Claire M. Radtke, Adam Knier, Sean A. Martin, Jane E. Dorweiler, Matthew E. Hudson, Anita L. Manogaran

This study shows that Hsp70 chaperones limit intracellular TTR aggregation in yeast, suggesting their decline may contribute to age-related TTR amyloidosis.

bioRxiv · Dec 16, 2025 · PreprintBiochemistry

Stress granules and protein aggregates reveal intracellular resource competition

Hannah E. Buchholz, Sean A. Martin, Jane E. Dorweiler, Derek C. Prosser, Emily Mitchell Sontag, Anita L. Manogaran

This study shows that competition for molecular chaperones limits stress granule disassembly, leading to their persistence and solidification, potentially contributing to neurodegenerative diseases.

bioRxiv · Nov 8, 2025 · PreprintCell Biology

Hsp70 chaperones, Ssa1 and Ssa2, limit poly(A) binding protein aggregation

Hannah E. Buchholz, Sean A. Martin, Jane E. Dorweiler, Claire M. Radtke, Adam Knier, Natalia B. Beans, Anita L. Manogaran

This study shows that Hsp70 chaperones Ssa1 and Ssa2 prevent aggregation of the poly(A) binding protein Pab1 in yeast, and their loss leads to age-related protein aggregation.

Molecular Biology of the Cell · Apr 9, 2025Peer-reviewedCell Biology

Actin Impacts The Late Stages Of Prion Formation And Prion Propagation

Douglas R. Lyke, Jane E. Dorweiler, Emily R. Legan, Brett T. Wisniewski, Emily E. Davis, Anita L. Manogaran

This study shows that actin networks influence both the formation and propagation of [PSI+] and [PIN+] prions in yeast by affecting prion particle inheritance and stability.

bioRxiv · Jun 1, 2017 · PreprintCell Biology