Author

Adam Knier

Marquette UniversityORCID 0000-0003-4726-6570Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Anita L. ManogaraniD· 2 shared Claire M. Radtke· 2 shared Jane E. Dorweiler· 2 shared Hannah E. BuchholziD· 1 shared Matthew E. HudsoniD· 1 shared Natalia B. Beans· 1 shared Sean A. MartiniD· 1 shared Sean A. Martin· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

Anita L. ManogaranORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintDec 16, 2025

Intracellular aggregation of the transthyretin protein is limited by Hsp70 chaperones

Claire M. Radtke, Adam Knier, Sean A. Martin…·Anita L. Manogaran

This study shows that Hsp70 chaperones limit intracellular TTR aggregation in yeast, suggesting their decline may contribute to age-related TTR amyloidosis.

DOI 10.64898/2025.12.14.694244

yeastprotein structure

𝕏 PostBluesky

Cell BiologyMolecular Biology of the CellPeer-reviewedApr 9, 2025

Hsp70 chaperones, Ssa1 and Ssa2, limit poly(A) binding protein aggregation

Hannah E. Buchholz, Sean A. Martin, Jane E. Dorweiler…·Anita L. Manogaran

This study shows that Hsp70 chaperones Ssa1 and Ssa2 prevent aggregation of the poly(A) binding protein Pab1 in yeast, and their loss leads to age-related protein aggregation.

4 citations

yeastproteomics

𝕏 PostBluesky