Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury
Sadi Quiñones, Jason C Wang, Elliot Kim, Samantha F. Bottom-Tanzer, Moritz Armbruster, Jéssica K. A. Macêdo, Tara R. Hawkinson, Roberto A. Ribas, Pankaj Kumar Singh, Lei Wu, Alex R. Cantrell, Parveen Kumar, Joshy George, Albert Tai, Michael J. Whalen, , Chris G. Dulla
The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.
bioRxiv · Jun 19, 2024 · PreprintNeuroscience