Joshy George

Clinical and Cross-Domain Validation of an LLM-Guided, Literature-Based Gene Prioritization Framework

The paper validates an LLM-guided gene prioritization framework for sepsis and tests its generalizability to obesity and infection using clinical and proteomic data.

Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

Causal network perturbation analysis identifies known and novel type-2 diabetes driver genes

The paper identifies driver genes for type 2 diabetes using causal network perturbation analysis and single-cell RNA sequencing in mouse models.

Calculating sample size for identifying cell subpopulation in single-cell RNA-seq experiments

The paper develops a statistical method to calculate the optimal number of cells needed to detect a rare subpopulation in scRNA-seq experiments, validated using dendritic cell and monocyte data.

Pan-cancer machine learning predictors of primary site of origin and molecular subtype

This paper develops machine learning models to predict the primary site of origin and molecular subtype of metastatic cancers using gene expression data from TCGA, achieving high accuracy across multiple cancer types.