Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform
Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Ritu Singh, Adam Skepner, Carol Khodier, Cerise Raffier, Ni Yan, Cameron Schluter, Xiao Yu, Mateusz Szuchnicki, Murugappan Sathappa, Josephine Kahn, , Peter G. Miller
This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.
bioRxiv · May 20, 2024 · PreprintCancer Biology