Author

Nancy Dumont

Broad InstituteORCID 0000-0002-6565-0851Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Alexandra E. GouldiD· 2 shared Adam P. SkepneriD· 1 shared Adam Samuel SperlingiD· 1 shared Alison CameroniD· 1 shared Amirshayan Chadeganipour· 1 shared Blanche C. IpiD· 1 shared Cameron Schluter· 1 shared Carly R. Langan· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Alexandra E. GouldORCID

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2 papers

Recent·Most cited

Dynamic inositol pyrophosphate synthesis is a targetable therapeutic opportunity in ovarian cancer.

Daniel P. Bondeson, David Husselbee, Saoirse Hanbury, Amirshayan Chadeganipour, Gabriel Mesa, Alison Cameron, Janhavi Y. Sawant, Carly R. Langan, Tuhina Bhattacharya, YuhJong Liu, Hajer Siala, Erin M Swanson, Mustafa Kocak, Karthik Srinivasan, Blanche C. Ip, , Todd R. Golub

This study evaluates strategies to inhibit XPR1 in ovarian cancer, showing that IP6K inhibitors effectively mimic XPR1 inhibition by blocking phosphate efflux and reducing tumor burden in xenograft models.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

Subrata Shaw, Wei Jiang, Jason S. Rush, Nancy Dumont, John Kim, Ritu Singh, Adam P. Skepner, Carol Khodier, Cerise Raffier, Zachary Murphy, Ni Yan, Cameron Schluter, Yu Xiao, Mateusz Szuchnicki, Murugappan Sathappa, , Peter Grant Miller

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

iScience · Feb 20, 2025Peer-reviewedCancer Biology