Author

Ni Yan

Broad InstitutePrimary ORCID profile (0000-0001-5775-5488 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Ni YaniD1 paper · AfaSci (United States)

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Cameron Schluter· 2 shared Adam S. Sperling· 1 shared Adam Samuel SperlingiD· 1 shared Adam Skepner· 1 shared Alexandra E. GouldiD· 1 shared Andrew E. H. EliaiD· 1 shared Carmen Da Silva· 1 shared Carol Khodier· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Cameron Schluter

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Distinct Proteasomal Pathways Drive Oncogenic PPM1D Activation

Ni Yan, Deumaya Shrestha, Cameron Schluter, Cyrus Jin, Edward Wang, Carmen Da Silva, Ilaria Gritti, Nikolaos Tsopoulidis, Ruxin Yang, Adam Samuel Sperling, Jonathan M. Tsai, Andrew E. H. Elia, Eric S. Fischer, Mikolaj Michal Slabicki, Eugene Oh, Peter Grant Miller

This study shows that truncating mutations in PPM1D shift its degradation pathway from ubiquitin-independent to UBR5-mediated, leading to increased PPM1D levels and oncogenic effects.

bioRxiv · Jun 9, 2026 · PreprintCell Biology

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Ritu Singh, Adam Skepner, Carol Khodier, Cerise Raffier, Ni Yan, Cameron Schluter, Xiao Yu, Mateusz Szuchnicki, Murugappan Sathappa, Josephine Kahn, , Peter G. Miller

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

bioRxiv · May 20, 2024 · PreprintCancer Biology