Author

David C. McKinney

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David C. McKinneyiD2 papers · Broad Institute

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam P. SkepneriD· 1 shared Adam Samuel SperlingiD· 1 shared Alexandra E. GouldiD· 1 shared Alison LeediD· 1 shared Andriy O. SamokhiniD· 1 shared Anna Szczeniowski· 1 shared Behnoush Hajian· 1 shared Bradley A. MaroniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Adam P. SkepnerORCID

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2 papers

Recent·Most cited

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype

Andriy O. Samokhin, Hyuk‐Soo Seo, Alison Leed, Behnoush Hajian, Gregory H. Bird, David C. McKinney, Progyaparamita Saha, Jacqueline Daum, Jamie A. Moroco, Jenna Yehl, David J. P. Kornfilt, Anna Szczeniowski, Elyse M. Petrunak, Steven L. Horner, Jay H. Kalin, , Bradley A. Maron

This study develops a covalent peptide targeting NEDD9-SH3 to inhibit endothelial migration and fibroproliferative remodeling in PAH by stabilizing the RT loop and modulating sulfatase-1 activity.

bioRxiv · Jul 10, 2025 · PreprintMolecular Biology

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

Subrata Shaw, Wei Jiang, Jason S. Rush, Nancy Dumont, John Kim, Ritu Singh, Adam P. Skepner, Carol Khodier, Cerise Raffier, Zachary Murphy, Ni Yan, Cameron Schluter, Yu Xiao, Mateusz Szuchnicki, Murugappan Sathappa, , Peter Grant Miller

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

iScience · Feb 20, 2025Peer-reviewedCancer Biology