Author

Yueying Cao

University of Massachusetts Chan Medical SchoolPrimary ORCID profile (0000-0001-5337-5760 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Yueying CaoiD1 paper · Macquarie University

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:CRISPR screen· 2 Research Focus:variant calling· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Wen XueiD· 3 shared Erik J. SontheimeriD· 2 shared Guangping GaoiD· 2 shared Aamir MiriD· 1 shared Alisha M. GruntmaniD· 1 shared April Destefano· 1 shared Athma A. PaiiD· 1 shared Boyang MaiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Wen XueORCID

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3 papers

Recent·Most cited

KRAS withdrawal in Cholangiocarcinoma leads to immune infiltration and tumor regression

Youwei Qiao, Matthew F. Yee, Chaitanya Naimesh Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus A. Ruscetti, Shun‐Qing Liang, Wen Xue

This study shows that removing KRASG12D in a mouse model of cholangiocarcinoma leads to tumor regression through immune infiltration and activation of CD8+ T cells.

Advanced Science · Dec 3, 2025Peer-reviewedCancer Biology

A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models

Jenny Gao, Nathan Bamidele, Debora Pires-Ferreira, Chunwei Zheng, April Destefano, Haoyang Cheng, Qiushi Tang, Yueying Cao, Jun Xie, Guangping Gao, Alisha M. Gruntman, Erik J. Sontheimer, Terence R. Flotte, Wen Xue

This paper demonstrates that a compact ABE corrects the PiZ mutation in AATD mouse models, reducing liver disease and improving lung function.

Molecular Therapy · Aug 28, 2025Peer-reviewedBioengineering

Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors

Raed Ibraheim, Phillip W.L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomás Rodríguez, Suk Namkung, Samantha J. Nelson, Eraj Shafiq Khokhar, Esther Mintzer, Stacy A. Maitland, Zexiang Chen, Yueying Cao, Emmanouela Tsagkaraki, Scot A. Wolfe, , Erik J. Sontheimer

This paper develops single-AAV vectors for precise in vivo genome editing using Nme2Cas9 with HDR templates or multiple sgRNAs, showing efficacy in treating HT-I and MPS-I mouse models.

Nature Communications · Nov 1, 2021Peer-reviewedMolecular Biology