Author

Jessica Kelly

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:machine learning (classical)· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A Herman· 1 shared A Robichaud· 1 shared Adam David DurbiniD· 1 shared Adrienne K. ScottiD· 1 shared Airn E. HartwigiD· 1 shared Alejandro Sweet-CorderoiD· 1 shared Anang A. ShelatiD· 1 shared Balakrishna KoneruiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A Herman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lamin A/C coordinates nuclear mechanics, chromatin architecture, and transcriptional homeostasis in skeletal muscle in vivo

Soham Ghosh, Kanita Hrustanovic, Stephanie Ellyse Schneider, Adrienne K. Scott, Jessica Kelly, Natalie Calahan, Benjamin Seelbinder, Brittany M. St. Martin, Xin Xu, Corey P. Neu

This study investigates how Lamin A/C disruption affects nuclear mechanics, chromatin architecture, and transcription in skeletal muscle in vivo, finding that it alters chromatin organization and gene expression in mechanically stiff tissues.

bioRxiv · Jun 2, 2026 · PreprintCell Biology

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers

Declan Bennett, Monika Wierdl, S Chakraborty, Jordan Johnson, Victoria Akingbehin, Daniel Estevez-Prado, Yuan Feng, Janeala J. Morsby, John Harper, Mohammad Ali Mohammad Nezhady, M Pan, Nicole Ocasio-Martinez, Jerrel Lewis Catlett, TB Nations, Neekesh V. Dharia, , Lillian M. Guenther

The paper develops ALTitude, a machine learning model to predict ALT status from whole genome sequencing data, identifies SMARCAL1 as a therapeutic target in ALT-driven cancers.

bioRxiv · May 28, 2026 · PreprintCancer Biology

A Highly Protective Clade 1 and 2 Cross-Reactive Pandemic Influenza Virus Vaccine Based on a 4th Generation Fully Deleted Adenoviral Vector of a Rare Serotype

Yan Qi, Richard Bowen, Airn E. Hartwig, Janae Wheeler Cull, Jessica Kelly, Xenia Klimenova, Uwe D. Staerz

The paper develops a cross-reactive influenza vaccine using a rare Ad6 vector that protects against clade 1 and 2 H5 viruses in mice and ferrets.

bioRxiv · Apr 30, 2025 · PreprintImmunology