The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells
Valentine Clerc, Jessica Valat, Xavier Grand, Nicolas Fontrodona, Matéo Bazire, Nicolas Rama, Didier Auboeuf, Benjamin Gibert, Franck Mortreux, Cyril F. Bourgeois
This study shows that MYCN and helicases DDX17/DDX5 have opposing roles in transcription termination and chimeric transcript production in neuroblastoma, with MYCN inhibiting helicase activity and promoting harmful RNA molecules.
bioRxiv · Feb 5, 2024 · PreprintMolecular Biology