Author

Valentine Clerc

Lyon 1 Université

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Cyril F. BourgeoisiD· 3 shared Didier AuboeufiD· 2 shared Franck MortreuxiD· 2 shared Jessica Valat· 2 shared Nicolas Fontrodona· 2 shared Xavier GrandiD· 2 shared Ange‐Line BrueliD· 1 shared Anne O’Donnell‐LuriaiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Cyril F. BourgeoisORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The MYCN oncoprotein and helicases DDX17 and DDX5 have opposite effects on the production of chimeric transcripts in neuroblastoma cells

Valentine Clerc, Jessica Valat, Xavier Grand, Nicolas Fontrodona, Matéo Bazire, Nicolas Rama, Didier Auboeuf, Benjamin Gibert, Franck Mortreux, Cyril F. Bourgeois

This study shows that MYCN and helicases DDX17/DDX5 have opposing roles in transcription termination and chimeric transcript production in neuroblastoma, with MYCN inhibiting helicase activity and promoting harmful RNA molecules.

bioRxiv · Feb 5, 2024 · PreprintMolecular Biology

Monoallelic de novo variants in DDX17 cause a novel neurodevelopmental disorder

Eleanor G. Seaby, Annie Godwin, Valentine Clerc, Géraldine Meyer-Dilhet, Xavier Grand, Tia Fletcher, Laloé Monteiro, Valério Carelli, Flavia Palombo, Marco Seri, Giulia Olivucci, Mina Grippa, Claudia Ciaccio, Stefano D’Arrigo, Maria Rosaria Iascone, , Sarah Ennis

The paper identifies de novo monoallelic DDX17 variants in 11 patients with neurodevelopmental disorders and shows DDX17 dysfunction causes neuronal migration and axon outgrowth defects in multiple models.

medRxiv · Oct 11, 2023 · PreprintGenetic & Genomic Medicine

SplicingLore: a web resource for studying the regulation of cassette exons by human splicing factors

Hélène Polvèche, Jessica Valat, Nicolas Fontrodona, Audrey Lapendry, Valentine Clerc, Stéphane Janczarski, Franck Mortreux, Didier Auboeuf, Cyril F. Bourgeois

SplicingLore provides a database of alternative exons regulated by 75 splicing factors, enabling analysis of splicing factor interactions and exon regulation.

Database · Jan 1, 2023Peer-reviewedGenomics