Phenotypic reversion and target prioritization for cellular inflammation via representation learning with foundation models
Daniel Wong, Mary E. Piper, Jiao Qiao, Max Russo, Pierre Jean, Djork-Arné Clevert, Jason D. Arroyo, Evanthia E. Pashos
The paper uses single-cell foundation models to identify genetic targets that reverse inflammation in endothelial cells by analyzing Perturb-seq data with and without proinflammatory stimulation.
bioRxiv · Mar 6, 2026 · PreprintBioinformatics