Author

Yuanyi Dai

Peking University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Chenjian LiiD· 2 shared Sushuang Zheng· 2 shared Bogdan BintuiD· 1 shared Carlos Chillón-Marinas· 1 shared Daniel D. ChildiD· 1 shared Don W. ClevelandiD· 1 shared Jerry Cheng· 1 shared Jianhang Yin· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Chenjian LiORCID

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Author profile →

3 papers

Recent·Most cited

Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington Disease

Sonia Vazquez‐Sanchez, Olatz Arnold-García, Carlos Chillón-Marinas, Roy Maimon, Jie Cui, Katelyn McNair, Yuanyi Dai, Norma Martínez Jiménez, Daniel D. Child, Leslie Michels Thompson, Jone López‐Erauskin, Bogdan Bintu, Don W. Cleveland

This paper develops a multimodal spatial transcriptomics approach to study CAG repeat expansion, huntingtin aggregation, and neuron loss in Huntington's Disease using human brain tissue.

Cell · Oct 1, 2026Peer-reviewedNeuroscience

Self-inactivating AAV-CRISPR at different ages enables sustained amelioration of Huntington's disease deficits in BAC226Q mice

Yuanyi Dai, Zuliayeti Abudujielili, Yunyi Ding, Wanping Huang, Jianhang Yin, Liqiong Ou, Jiazhi Hu, Sushuang Zheng, Chenjian Li

Self-inactivating CRISPR targeting mutant huntingtin in HD mice achieved long-term rescue of neural pathology, motor deficits, weight loss and survival.

Science Advances · Mar 18, 2026Peer-reviewedNeuroscience

A novel and accurate full-length HTT mouse model for Huntington's disease

Sushila A Shenoy, Sushuang Zheng, Wencheng Liu, Yuanyi Dai, Yuanxiu Liu, Zhipeng Hou, Susumu Mori, Yi Tang, Jerry Cheng, Wenzhen Duan, Chenjian Li

This paper describes the creation of a novel HD mouse model, BAC226Q, which accurately recapitulates age-dependent and progressive HD-like phenotypes.

eLife · Jan 4, 2022Peer-reviewedNeuroscience